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busulfan

busulfan

Pronunciation: bue SUL fan

Brand: Busulfex, Myleran

What is the most important information I should know about busulfan?

Multum calldoc

Busulfan can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Multum emt

Busulfan can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medication.

What is busulfan?

Busulfan is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Busulfan is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). Busulfan is not a cure for leukemia.

Busulfan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using busulfan?

Multum donot

You should not use busulfan if you are allergic to it.

To make sure you can safely take busulfan, tell your doctor if you have any of these other conditions:

  • a weak immune system (bone marrow depression) caused by other cancer medications or radiation treatment;
  • epilepsy or other seizure disorder;
  • history of head injury; or
  • a history of lung or breathing problems.
Multum nopreg

FDA pregnancy category D. Do not use busulfan if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication may affect fertility (your ability to have children), whether you are a man or a woman.

Multum nobrfeed

It is not known whether busulfan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Some people treated with busulfan have developed new forms of cancer. Talk to your doctor about your specific risks and benefits of using this medication.

How should I use busulfan?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum water

Take the busulfan tablet with a full glass of water.

Busulfan injection is given through a needle placed into a vein in your upper chest (central IV). You will receive this injection in a clinic or hospital setting. You will also receive other medications to help prevent certain side effects of busulfan.

Busulfan can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

Multum emt

Busulfan can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medication.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Since busulfan injection is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using busulfan?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

This medicine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Do not receive a "live" vaccine while using busulfan, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the possible side effects of busulfan?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • pale skin, feeling light-headed or short of breath, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, chills, sore throat, flu symptoms, loss of appetite, weight loss, unusual weakness, mouth and throat ulcers, rapid and shallow breathing;
  • signs of infection such as fever, chills, sore throat, flu symptoms, loss of appetite, weight loss, unusual weakness, mouth and throat ulcers, rapid and shallow breathing;
  • weight gain, stomach swelling or tenderness, jaundice (yellowing of the skin or eyes);
  • coughing up blood;
  • stomach pain, vomiting, sharp chest pain, trouble breathing;
  • lower back pain, blood in your urine, little or no urinating;
  • confusion, jerking muscle movements, muscle tightness or contraction, overactive reflexes, muscle weakness or limp feeling, leg discomfort, numbness or tingly feeling around your mouth;
  • fast, slow, or uneven heart rate;
  • weak pulse, confusion, fainting, seizure; or
  • persistent cough, congestion, low fever, feeling short of breath (these symptoms may occur several months or years after using busulfan).
  • seizure (convulsions); or

Common side effects may include:

  • headache;
  • diarrhea, constipation, nausea, upset stomach;
  • flushing (warmth, redness, or tingly feeling);
  • swelling or irritation around the IV needle;
  • missed menstrual periods; or
  • hair loss, darkened skin color.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect busulfan?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with busulfan, especially:

  • acetaminophen (Tylenol);
  • itraconazole; or
  • phenytoin.

This list is not complete. Other drugs may interact with busulfan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about busulfan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 7.02. Revision date: 7/1/2013.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Last modified on: 21 November 2014


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