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procarbazine

procarbazine

Pronunciation: pro CAR ba zeen

Brand: Matulane

What is the most important information I should know about procarbazine?

Multum nopreg

Do not use procarbazine if you are pregnant. It could harm the unborn baby.

Multum donot

You should not take procarbazine if you are allergic to it, or if you have bone marrow suppression.

Before you take procarbazine, tell your doctor if you have liver or kidney disease, low white or red blood cell counts, low platelet counts, fluid retention, or if you have received other cancer medications or radiation within the past 30 days.

Multum noalcohol

Do not drink alcohol while taking procarbazine.

Multum smoking

Avoid smoking during your treatment.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Multum donot

Do not receive a "live" vaccine while taking procarbazine. The vaccine may not work as well during this time.

Multum donot

While you are taking procarbazine, you must not drink alcohol or eat foods that are high in tyramine, listed in the "What should I avoid while taking procarbazine?" section of this leaflet. Eating tyramine while you are taking procarbazine can raise your blood pressure to dangerous levels, causing life-threatening symptoms.

What is procarbazine?

Procarbazine is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Procarbazine is given with other cancer medications to treat Hodgkin's Disease (a type of blood cancer).

Procarbazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking procarbazine?

Multum donot

You should not take procarbazine if you are allergic to it, or if you have bone marrow suppression.

To make sure you can safely use procarbazine, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • anemia (low red blood cells);
  • low levels of platelets in the blood;
  • low white blood cell counts;
  • fluid retention; or
  • if you have received other cancer medications or radiation within the past 30 days.
Multum nopreg

FDA pregnancy category D. Do not use procarbazine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Procarbazine can lower sperm count in men, which may affect fertility (your ability to have children).

Multum nobrfeed

It is not known whether procarbazine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking procarbazine.

How should I take procarbazine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum donot

Procarbazine can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid activities that may increase your risk of bleeding or injury.

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe nausea and vomiting, tremors, or seizure (convulsions).

What should I avoid while taking procarbazine?

Multum noalcohol

Do not drink alcohol. Procarbazine can cause unpleasant side effects when you drink alcohol.

Multum smoking

Avoid smoking during your treatment. Smoking may increase your risk of lung cancer while taking procarbazine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Multum donot

Do not receive a "live" vaccine while using procarbazine. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), oral polio, typhoid, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine.

Multum donot

While you are taking procarbazine, you should avoid foods that are high in tyramine, including:

  • avocados, bananas, figs, papaya, raisins, and sauerkraut;
  • beef or chicken liver, meats prepared with tenderizer, bologna, pepperoni, summer sausage, game meat, meat extracts;
  • pickled or smoked fish, anchovies, dried fish, herring, caviar, shrimp paste;
  • beer (alcoholic and nonalcoholic), wine (especially red wine), champagne, sherry, vermouth, and other distilled spirits;
  • caffeine (including coffee, tea, cola), ginseng;
  • cheese -- especially aged or processed cheeses (American, blue, boursault, brie, camembert, cheddar, gruyere, mozzarella, parmesan, romano, roquefort, Swiss);
  • chocolate;
  • sour cream and yogurt;
  • soy sauce, miso soup, bean curd, fava beans; or
  • yeast extracts.

Eating tyramine while you are taking procarbazine can raise your blood pressure to dangerous levels, causing life-threatening side effects.

What are the possible side effects of procarbazine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery;
  • feeling like you might pass out;
  • numbness, burning pain, or tingly feeling;
  • confusion, hallucinations, problems with vision or speech, trouble with walking or daily activities;
  • feeling unsteady, loss of balance or coordination;
  • tremors, seizure (convulsions);
  • cough, chest pain, trouble breathing;
  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • white patches or sores inside your mouth or on your lips;
  • jaundice (yellowing of the skin or eyes);
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • mild nausea, vomiting, loss of appetite, stomach pain;
  • dry mouth, constipation, mild diarrhea;
  • mild itching or rash, temporary hair loss;
  • muscle of joint pain;
  • headache, dizziness, feeling tired;
  • urinating more than usual; or
  • changes in your menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect procarbazine?

Multum dizzy

Before taking procarbazine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They may increase certain side effects of procarbazine.

Tell your doctor about all other medicines you use, especially:

  • blood pressure medication;
  • an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), and others;
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • diet pills, stimulants, or ADHD medication such as Adderall or Ritalin; or
  • phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), or trifluoperazine (Stelazine).

This list is not complete and other drugs may interact with procarbazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about procarbazine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 4.01. Revision date: 8/31/2012.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Last modified on: 2 April 2014


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