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hydrochlorothiazide and amiloride

hydrochlorothiazide and amiloride

Pronunciation: hy dro klor oh THI a zide and a MIL o ride

Brand: Moduretic 5-50

Amiloride-HCTZ 5-50-END

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Amiloride-HCTZ 5-50-MYL

round, orange, imprinted with M 577

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Amiloride-HCTZ-BAR

round, yellow, imprinted with barr, 555 483

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Moduretic 5-50

diamond, peach, imprinted with M, MSD 917

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What is the most important information I should know about hydrochlorothiazide and amiloride?

Multum donot

You should not use this medication if you have kidney disease, urination problems, diabetes, or high levels of potassium in your blood. Do not use potassium supplements while you are taking hydrochlorothiazide and amiloride.

Before using this medication, tell your doctor if you have heart disease, cirrhosis or other liver disease, glaucoma, a breathing disorder, gout, lupus, an allergy to sulfa drugs or penicillin, or a pancreas disorder. Tell your doctor if you use steroids or other blood pressure medicines.

Multum noalcohol

Drinking alcohol can increase certain side effects of hydrochlorothiazide and amiloride.

Multum donot

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking hydrochlorothiazide and amiloride.

There are many other drugs that can interact with hydrochlorothiazide and amiloride. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What is hydrochlorothiazide and amiloride?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Amiloride is a potassium sparing-diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

The combination of hydrochlorothiazide and amiloride is used to treat fluid retention (edema) and high blood pressure (hypertension).

Hydrochlorothiazide and amiloride may also be used for purposes not listed in this medication guide.

What should I discuss with my doctor before taking hydrochlorothiazide and amiloride?

Multum donot

You should not use this medication if you are allergic to hydrochlorothiazide or amiloride, or if you have:

  • kidney disease or are unable to urinate;
  • high potassium levels (hyperkalemia); or
  • if you are taking potassium supplements.

To make sure you can safely take hydrochlorothiazide and amiloride, tell your doctor if you have any of these other conditions:

  • diabetes;
  • heart disease;
  • cirrhosis or other liver disease;
  • glaucoma;
  • a breathing disorder;
  • gout;
  • lupus;
  • an allergy to sulfa drugs or penicillin;
  • a pancreas disorder; or
  • if you are using another blood pressure medication or a steroid.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and amiloride.

How should I take hydrochlorothiazide and amiloride?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum food

Take hydrochlorothiazide and amiloride with food.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Multum emt

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Multum rt

Store at room temperature away from moisture, heat, and light. Do not freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.

What should I avoid while taking hydrochlorothiazide and amiloride?

Multum noalcohol

Drinking alcohol can increase certain side effects of hydrochlorothiazide and amiloride.

Multum donot

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking hydrochlorothiazide and amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What are the possible side effects of hydrochlorothiazide and amiloride?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • numbness or tingly feeling;
  • muscle pain or weakness;
  • slow, fast, or uneven heartbeat;
  • feeling drowsy, restless, or light-headed;
  • urinating less than usual or not at all;
  • dry mouth, increased thirst, tiredness, nausea, vomiting;
  • shallow breathing;
  • tremors, confusion; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild nausea or vomiting;
  • gas, stomach pain; or
  • skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and amiloride?

Multum dizzy

Tell your doctor if you regularly use other medicines that make you light-headed (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to the side effects of hydrochlorothiazide and amiloride.

Tell your doctor about all other medicines you use, especially:

  • cyclosporine (Neoral, Sandimmune, Gengraf);
  • tacrolimus (Prograf);
  • lithium (Eskalith, LithoBid);
  • digoxin (Lanoxin);
  • steroids (prednisone and others);
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • insulin or oral diabetes medication;
  • other blood pressure medications;
  • an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
  • candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), or valsartan (Diovan); or
  • indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with hydrochlorothiazide and amiloride. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and amiloride.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 4.02. Revision date: 3/12/2012.

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This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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Last modified on: 2 April 2014


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