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sibutramine

sibutramine

Pronunciation: si BUE tra meen

Brand: Meridia

Meridia 10 mg

blue/white, imprinted with MERIDIA, 10

Image of Meridia 10 mg
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What is the most important information I should know about sibutramine?

Sibutramine was withdrawn from the U.S. market in October 2010.

Multum donot

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body.

Multum donot

You should not take sibutramine if you are allergic to it, or if you have severe or uncontrolled high blood pressure, an eating disorder (anorexia or bulimia), if you are taking stimulant diet pills, or if you have a history of coronary artery disease, stroke, or heart disease.

Before taking sibutramine, tell your doctor if you have glaucoma, high blood pressure, liver or kidney disease, depression, underactive thyroid, seizures, a bleeding disorder, a history of gallstones, or if you are older than 65 or younger than 16.

Tell your doctor about all prescription and over-the-counter medications you use, especially antidepressants, cold or allergy medication, narcotic pain medicine, or migraine headache medicines.

Multum donot

Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks along with a low calorie diet.

What is sibutramine?

Sibutramine was withdrawn from the U.S. market in October 2010.

Sibutramine affects chemicals in the brain that affect weight maintenance.

Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.

Sibutramine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking sibutramine?

Multum donot

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body.

Multum donot

You should not take this medication if you are allergic to sibutramine, or if you have:

  • severe or uncontrolled hypertension (high blood pressure);
  • an eating disorder (anorexia or bulimia);
  • a history of coronary artery disease (atherosclerosis);
  • a history of heart disease (congestive heart failure, heart rhythm disorder);
  • a history of heart attack or stroke; or
  • if you are taking stimulant diet pills.

If you have any of these other conditions, you may need a sibutramine dose adjustment or special tests:

  • glaucoma;
  • high blood pressure;
  • liver disease;
  • kidney disease;
  • depression;
  • underactive thyroid;
  • epilepsy or seizure disorder;
  • a bleeding or blood clotting disorder;
  • a history of gallstones; or
  • if you are older than 65 or younger than 16.
Multum nopreg

FDA pregnancy category C. It is not known whether sibutramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using sibutramine.

Multum nobrfeed

It is not known whether sibutramine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medication to anyone younger than 16 years old.

How should I take sibutramine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Sibutramine is usually taken once daily. Follow your doctor's instructions.

Your doctor may occasionally change your dose to make sure you get the best results.

Sibutramine can be taken with or without food.

Multum donot

You should lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks.

Your blood pressure and pulse will need to be checked often. Visit your doctor regularly.

Sibutramine should not be taken for longer than 2 years.

Multum rt

Store at room temperature away from moisture, heat, and light.

Multum donot

Do not share sibutramine with another person. Keep the medication in a place where others cannot get to it.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, dizziness, and fast heart rate.

What should I avoid while taking sibutramine?

Multum dizzy

Sibutramine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum donot

Do not take any other prescription or over-the-counter weight-loss products without your doctor's advice.

Avoid taking cough and cold or allergy medications while taking sibutramine.

Multum noalcohol

Avoid drinking alcohol while taking sibutramine.

What are the possible side effects of sibutramine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using sibutramine and call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeats;
  • new or worsening shortness of breath;
  • agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;
  • very stiff (rigid) muscles, high fever, sweating, confusion, feeling like you might pass out;
  • easy bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure);
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling; or
  • sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance.

Less serious side effects may include:

  • dry mouth, upset stomach;
  • changes in appetite;
  • constipation, stomach pain;
  • headache, back pain, joint pain;
  • feeling nervous, dizzy, or depressed;
  • flu symptoms, runny or stuffy nose, sore throat, cough;
  • warmth, redness, or tingly feeling under your skin;
  • trouble sleeping (insomnia); or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sibutramine?

Multum dizzy

Before using sibutramine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by sibutramine.

Ask your doctor before taking any decongestants, cough medicine, or other diet pills.

The following drugs can interact with sibutramine. Tell your doctor if you are using any of these:

  • lithium (Lithobid, Eskalith, and others);
  • tryptophan or L-tryptophan;
  • ketoconazole (Nizoral);
  • an antibiotic such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
  • an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), and others;
  • ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine).
  • migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or
  • narcotic pain medication such as fentanyl (Actiq, Duragesic, Fentora, Onsolis), meperidine (Demerol), pentazocine (Talwin).

This list is not complete and other drugs may interact with sibutramine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sibutramine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 5.02. Revision date: 12/15/2010.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Last modified on: 2 April 2014


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