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metformin and rosiglitazone

metformin and rosiglitazone

Pronunciation: met FOR min and ROE zi GLI ta zone

Brand: Avandamet

Avandamet 1000 mg-4 mg

oval, pink, imprinted with gsk, 4/1000

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Avandamet 500 mg-2 mg

oval, pink, imprinted with gsk, 2/500

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Avandamet 500 mg-4 mg

oval, orange, imprinted with gsk, 4/500

Image of Avandamet 500 mg-4 mg
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Avandamet 1000 mg-2 mg

oval, yellow, imprinted with gsk, 2/1000

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What is the most important information I should know about metformin and rosiglitazone?

Multum donot

You should not use this medicine if you have severe or uncontrolled heart failure, or severe kidney problems. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Metformin and rosiglitazone is not recommended for use with insulin, and is not for treating type 1 diabetes.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and rosiglitazone.

Multum calldoc

Metformin and rosiglitazone can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Multum emt

This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

What is metformin and rosiglitazone?

Metformin and rosiglitazone is a combination of two oral diabetes medicines that help control blood sugar levels. This medicine is for people with type 2 diabetes, and is not for treating type 1 diabetes.

Metformin and rosiglitazone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking metformin and rosiglitazone?

Multum donot

You should not use metformin and rosiglitazone if you are allergic to it, or if you have:

  • severe or uncontrolled heart failure;
  • severe kidney problems;
  • metabolic acidosis; or
  • if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and rosiglitazone.

Multum emt

Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk.

To make sure this medication is safe for you, tell your doctor if you have:

  • heart disease, or a history of heart attack or stroke;
  • liver disease; or
  • eye problems caused by diabetes.

Taking this medicine may increase your risk of heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with metformin and rosiglitazone.

Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking medicine that contains rosiglitazone. Talk with your doctor if you are concerned about this possibility.

Multum nopreg

FDA pregnancy category C. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Some women using metformin and rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

Multum nobrfeed

It is not known whether metformin and rosiglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take metformin and rosiglitazone?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum food

Take this medicine with food if it upsets your stomach.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Multum dizzy

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Multum donot

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

If you take extra vitamin B12 while you are taking metformin and rosiglitazone, take only the amount of vitamin B12 that your doctor has prescribed.

Metformin and rosiglitazone is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking metformin and rosiglitazone?

Multum noalcohol

Avoid drinking alcohol while taking metformin and rosiglitazone.

What are the possible side effects of metformin and rosiglitazone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum emt

Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Multum calldoc

Call your doctor at once if you have:

  • chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • pale skin, easy bruising or bleeding, weakness;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • changes in your vision.

Common side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • headache; or
  • upset stomach, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect metformin and rosiglitazone?

Multum donot

Tell your doctor if you use insulin. Taking metformin and rosiglitazone while you are using insulin may increase your risk of serious heart problems.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with metformin and rosiglitazone, especially:

  • cimetidine;
  • gemfibrozil; or
  • an antibiotic--rifampin, trimethoprim, vancomycin.

You may be more likely to have hyperglycemia (high blood sugar) if you also take other drugs that can raise blood sugar, such as:

  • isoniazid;
  • steroids (prednisone and others);
  • niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
  • phenothiazines (Compazine and others);
  • thyroid medicine (Synthroid and others);
  • birth control pills and other hormones; and
  • diet pills or medicines to treat asthma, colds or allergies.

These lists are not complete and many other medicines can increase or decrease the effects of metformin and rosiglitazone on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about metformin and rosiglitazone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 12.01. Revision date: 3/5/2014.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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Last modified on: 21 November 2014


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