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ustekinumab

ustekinumab

Pronunciation: YOO sti KIN ue mab

Brand: Stelara, Stelara PFS

What is the most important information I should know about ustekinumab?

Multum donot

You should not use this medication if you are allergic to ustekinumab or if you have received a BCG (Bacillus Calmette and Guérin) vaccine within the past year (12 months).

BCG vaccine should not be given for at least 1 year after you receive your last dose of ustekinumab.

Before using ustekinumab, tell your doctor if you have an active infection, a history of tuberculosis or recurrent infections, high blood pressure, a weak immune system, or if you are receiving phototherapy (light therapy).

Your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Make sure you are current on all vaccines before you start treatment with ustekinumab.

Ustekinumab can make it easier for you to get sick. Avoid being near people who have colds, the flu, or other contagious illnesses.

Multum emt

Contact your doctor right away if you have signs of infection such as fever, chills, sore throat, flu symptoms, swollen glands, unusual weakness, mouth and throat ulcers, rapid heart rate, rapid and shallow breathing, swelling or redness, pain or burning when you urinate, blood in your urine, severe stomach pain, changes in your bowel habits, cough with yellow or green mucus, stabbing chest pain, or severe headache with confusion, vision problems, or seizure.

Treatment with ustekinumab may increase your risk of developing cancer. Talk to your doctor about your individual risk.

What is ustekinumab?

Ustekinumab is an immunosuppressant that reduces the effects of a chemical substance in the body that can cause inflammation.

Ustekinumab is used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults.

Ustekinumab may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before using ustekinumab?

Multum donot

You should not use this medication if you are allergic to ustekinumab or if you have received a BCG (Bacillus Calmette and Guérin) vaccine within the past year (12 months).

To make sure you can safely use ustekinumab, tell your doctor if you have other medical conditions, especially:

  • an active infection;
  • a history of chronic infections;
  • a history of tuberculosis;
  • high blood pressure;
  • a weak immune system;
  • if you are receiving phototherapy (light therapy); or
  • if you have ever received allergy shots or used an Epi-Pen (for severe allergic reaction).

FDA pregnancy category B. Ustekinumab is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Ustekinumab can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Treatment with ustekinumab may increase your risk of developing cancer. Talk to your doctor about your individual risk.

How should I use ustekinumab?

Before you start treatment with ustekinumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Ustekinumab is given as an injection under the skin. Your doctor, nurse, or other healthcare provider will give you this injection.

Ustekinumab injections are usually given every 12 weeks, but your first two injections will be 4 weeks apart. Follow your doctor's instructions.

Multum emt

Ustekinumab can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

Multum emt

Contact your doctor right away if you have signs of infection such as fever, chills, sore throat, flu symptoms, swollen glands, unusual weakness, mouth sores, swelling or redness, severe stomach pain, cough with mucus, or severe headache. These may be early signs of a severe infection.

You must remain under the care of a doctor while you are receiving ustekinumab.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ustekinumab injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using ustekinumab?

Avoid injecting this medication into skin that is bruised, red, tender, or hardened.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Multum donot

Do not receive a "live" vaccine while using ustekinumab, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

BCG vaccine should not be given for at least 1 year after you receive your last dose of ustekinumab.

Non-live vaccines (including flu shots) may not work as well during your treatment, and may not fully protect you from disease. Make sure you are current on all vaccines before you begin treatment with ustekinumab.

What are the possible side effects of ustekinumab?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever, chills, sore throat, flu symptoms, swollen glands, unusual weakness;
  • mouth and throat ulcers, rapid heart rate, rapid and shallow breathing, fainting;
  • swelling, pain, tenderness, or redness anywhere on your body;
  • pain or burning when you urinate, blood in your urine;
  • stomach pain that is sudden and severe or comes on slowly, changes in bowel habits (diarrhea or constipation);
  • cough with yellow or green mucus;
  • stabbing chest pain, feeling short of breath; or
  • severe headache, confusion, change in mental status, vision problems, and/or seizure (convulsions).

Less serious side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • headache, tired feeling;
  • mild diarrhea; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ustekinumab?

Tell your doctor about all other medications you use, especially:

  • drugs that weaken your immune system (such as cancer medicine or steroids);
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);
  • levothyroxine (Synthroid, Levothroid);
  • lithium (Eskalith, Lithobid);
  • pimozide (Orap);
  • sirolimus (Rapamune) or tacrolimus (Prograf);
  • theophylline (Elixophyllin, Theo-24, Uniphyl);
  • ergot medicine such as ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), ethosuximide (Zarontin), phenytoin (Dilantin), or valproic acid (Depakene, Stavzor); or
  • a heart rhythm medication such as disopyramide (Norpace), procainamide (Procan, Pronestyl), or quinidine (Quin-G).

This list is not complete and other drugs may interact with ustekinumab. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about ustekinumab.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 3.01. Revision date: 9/13/2012.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Last modified on: 2 April 2014


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