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morphine and naltrexone

morphine and naltrexone

Pronunciation: MOR feen and nal TREX one

Brand: Embeda

What is the most important information I should know about morphine and naltrexone?

Multum donot

You should not use morphine and naltrexone if you have severe asthma or breathing problems, or a bowel obstruction called paralytic ileus.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Morphine can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose. Morphine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum emt

MISUSE OF NARCOTIC MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Multum nopreg

Tell your doctor if you are pregnant. Morphine and naltrexone may cause life-threatening addiction and withdrawal symptoms in a newborn.

Multum noalcohol

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with morphine and naltrexone.

What is morphine and naltrexone?

Morphine is an opioid pain medication. An opioid is sometimes called a narcotic.

Naltrexone is a special narcotic drug that blocks the effects of other narcotic medicines and alcohol.

Morphine and naltrexone is a combination medicine used to treat moderate to severe pain when around-the-clock pain relief is needed for a long time period.

Morphine and naltrexone is an extended-release opioid pain medicine that is not for use on an as-needed basis for pain.

Morphine and naltrexone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking morphine and naltrexone?

Do not use morphine and naltrexone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Multum donot

You should not use morphine and naltrexone if you have ever had an allergic reaction to a narcotic medicine, or if you have:

  • severe asthma or breathing problems; or
  • a bowel obstruction called paralytic ileus.

You should not use morphine and naltrexone unless you are already using a similar opioid medicine and are tolerant to it. Opioid medicines include codeine (Tylenol #3), fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), oxycodone (OxyContin, Combunox, Roxicodone, Percocet), and many others. Ask your doctor if you are not sure you are opioid-tolerant.

To make sure morphine and naltrexone is safe for you, tell your doctor if you have:

  • any type of breathing problem or lung disease;
  • a history of head injury, brain tumor, or seizures;
  • a history of drug abuse, alcohol addiction, or mental illness;
  • enlarged prostate, urination problems;
  • liver or kidney disease;
  • curvature of the spine that affects your breathing;
  • Addison's disease (an adrenal gland disorder);
  • problems with your gallbladder, pancreas, or thyroid.

Morphine and naltrexone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Multum nopreg

FDA pregnancy category C. It is not known whether morphine and naltrexone will harm an unborn baby. Morphine and naltrexone may cause breathing problems, behavior changes, or life-threatening addiction and withdrawal symptoms in your newborn if you use the medication during pregnancy. Tell your doctor if you are pregnant.

Multum nobrfeed

Morphine and naltrexone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using morphine and naltrexone.

How should I use morphine and naltrexone?

Follow all directions on your prescription label. Morphine can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Multum habit

Morphine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away morphine and naltrexone is against the law.

Stop taking all other around-the-clock narcotic pain medications when you start taking morphine and naltrexone.

You may take morphine and naltrexone with or without food. Morphine and naltrexone is usually taken 1 or 2 times each day. Each dose should be spaced at least 12 hours apart. Follow your doctor's instructions.

Multum nocrush

Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose.

To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Mix only one dose and swallow this mixture right away without chewing. Drink a glass of water to make sure all the medicine has been swallowed. Flush the empty capsule down a toilet.

Do not stop using morphine and naltrexone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using morphine and naltrexone.

Multum donot

Never crush or break a morphine and naltrexone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of morphine and naltrexone and similar prescription drugs.

Multum rt

Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Morphine and naltrexone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

After you have stopped using this medication, flush any unused pills down the toilet. Throw away any unused liquid morphine and naltrexone that is older than 90 days.

What happens if I miss a dose?

Since morphine and naltrexone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Multum donot

Morphine and naltrexone is not for use on an as-needed basis for pain.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A morphine and naltrexone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while using morphine and naltrexone?

Multum noalcohol

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with morphine and naltrexone. Check your food and medicine labels to be sure these products do not contain alcohol.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how morphine and naltrexone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

What are the possible side effects of morphine and naltrexone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; chest pain, anxiety, pounding heartbeats, fainting; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • weak or shallow breathing;
  • a light-headed feeling, like you might pass out;
  • seizure (convulsions); or
  • agitation, hallucinations, fast heart rate, overactive reflexes, loss of coordination.

Common side effects may include:

  • constipation, nausea, vomiting, stomach pain;
  • drowsiness, dizziness; or
  • headache, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect morphine and naltrexone?

Multum dizzy

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking morphine and naltrexone with a sleeping pill, other narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with morphine and naltrexone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about morphine and naltrexone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 5.01. Revision date: 1/13/2014.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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Last modified on: 21 November 2014


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