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K+ Sink Uncovered: How Tumors Trap Potassium to Evade Immunity

Understanding how tumors manipulate their microenvironment is key to improving cancer immunotherapy. A recent study has revealed that PKM2, a metabolic enzyme released from necrotic tumor cells, acts as a "potassium sink" within tumor interstitial fluid (TIF). This phenomenon traps potassium ions (K+), creating an immunosuppressive environment that dampens CD8+ T cell activity and promotes tumor growth.

June 25, 2025


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