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From Metabolism to Immunity: A Hidden Switch in Breast Cancer Uncovered

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment. Acting from within the cell nucleus, PHGDH suppresses the activity of two critical genes--GLUD1 and GLS2--that drive glutamine metabolism, a pathway vital to immune cell function.

July 7, 2025


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