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Berberine Alleviates Myocardial Diastolic Dysfunction by Modulating Drp1-Mediated Mitochondrial Fission and Ca2+ Homeostasis in a Murine Model of HFpEF

This study uses a "two-hit" HFpEF mouse model, finds the model has exercise intolerance and diastolic dysfunction with myocardial/mitochondrial abnormalities, and shows berberine alleviates these via improving autophagy, inhibiting mitochondrial fragmentation and Ca2+ overload.

September 29, 2025


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September 29 2025

Angell Street Psychiatry
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