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Wake Forest University School of Medicine Scientists Uncover Cancer Treatment Strategy That Pushes Tumor Cells Past Their Breaking Point

Researchers have uncovered a promising cancer treatment strategy by targeting a mitochondrial protein called peroxiredoxin-3 (PRX3). PRX3 normally acts as a cleanup system inside cancer cells, breaking down hydrogen peroxide before it becomes toxic. The team discovered a compound fragment that binds to PRX3 and switches it off, causing hydrogen peroxide to accumulate beyond the cell's tolerance.

November 4, 2025


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