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Researchers Identify Rare Mutation That Predicts Strong Immunotherapy Response in Colorectal Cancer

A specific subset of POLE gene mutation, called loss-of-proofreading (LOP) mutations, makes colorectal tumors highly responsive to immunotherapy Patients with the specific POLE mutations had long-lasting responses when treated with immunotherapy, whereas those with other POLE mutations did not see similar benefits A new study led by researchers at The University of Texas MD Anderson Cancer Center shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer (CRC).

November 20, 2025


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