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Enantioselective Maternal Transfer of Pesticide Metabolite and Its Thyroid Effects

Estimating the multigenerational effects of chiral pesticide metabolites is essential for fully understanding their ecological impacts. This study demonstrated that S-o,p'-DDD accumulated preferentially in adult zebrafish and transferred more efficiently to their offspring compared to the R-enantiomer, leading to pronounced developmental defects and endocrine disruption across both generations. Molecular docking against key thyroid-related proteins provided a mechanistic explanation for this stereospecific toxicity. These findings suggest that evaluating only racemic mixtures may underestimate real-world hazards.

November 26, 2025


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