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Study Reveals Molecular 'Switch' That Turns on Inflammation in Obesity

A team led by UT Southwestern Medical Center researchers has uncovered a molecular pathway that links obesity to widespread inflammation, providing long-sought insight into why obesity increases the risk of Type 2 diabetes, cardiovascular disease, fatty liver disease, and certain cancers. The findings, published in Science, identify a molecular "switch" that triggers this inflammation and point to potential new therapeutic targets.

January 15, 2026


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