News for Healthier Living

Targeting Stem-Like Cells in Colorectal Cancer

Colorectal cancer often returns not because the main tumor survives, but because a small population of stem-like cancer cells can resist treatment, seed new growth, and drive aggressive spread. This study identifies BEX2 as an important suppressor of those dangerous traits. When BEX2 levels were high, colorectal cancer cells showed weaker stemness, reduced tumor-forming ability, lower drug resistance, and less invasive behavior. Mechanistically, the researchers found that BEX2 destabilizes MCL1, which in turn dampens Hedgehog signaling, a pathway closely tied to cancer stem cell maintenance. The findings point to a new molecular route that could be exploited to curb relapse and improve therapeutic response in colorectal cancer.

April 14, 2026


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