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How Acupuncture Rewires Neuro-Immune Circuits to Treat Disease at Its Root

Acupuncture has long been used to restore physiological balance, yet its biological basis has remained elusive. Recent research reveals that acupuncture operates through neuro-immune regulatory circuits rather than isolated local effects. Mechanical stimulation at acupoints is converted into neural electrical and biochemical signals, reshaping local immune microenvironments and triggering coordinated responses across the nervous system. These signals engage somatosensory pathways, autonomic nerves, and the gut-brain axis to recalibrate immune homeostasis at both local and systemic levels. By mapping how physical stimulation is encoded into neural activity and translated into immune regulation, the research reframes acupuncture as a form of targeted neuromodulation with broad relevance for inflammatory and immune-related diseases.

April 22, 2026


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