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Mapping Cancer's Hidden Protein Control System

Chemical changes added to proteins after they are made are emerging as a powerful way to understand how cancers grow, spread, evade immunity, and resist treatment. A new review brings these changes, known as protein post-translational modifications (PTMs), into a systems-level view of cancer biology. Rather than treating phosphorylation, acetylation, methylation, ubiquitination, glycosylation, lactylation, and other PTMs as isolated events, considering them together with their writers, erasers, readers, and modification sites as an integrated PTM system may facilitate earlier disease diagnostic, predict treatment response, and reveal new therapeutic targets for precision oncology.

June 9, 2026


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