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Amyloid Removal May Reduce Tau Buildup and Neurodegeneration in Alzheimer's Disease for Years After Treatment, Penn Medicine Report Finds

An analysis of the brain of a deceased Alzheimer's disease (AD) clinical trial participant found that regions where an anti-amyloid therapy successfully cleared amyloid plaques showed little to no evidence of tau tangles, a hallmark of AD closely linked to neurodegeneration and cognitive decline. In contrast, neighboring areas where amyloid remained showed substantially more tau pathology and signs of ongoing brain damage.

July 13, 2026


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Angell Street Psychiatry
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