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Two Hours of Sleep Restored: UK Researchers Make Alzheimer's Breakthrough

In a study published in the journal Alzheimer's & Dementia, a team led by Shannon L. Macauley, Ph.D., an associate professor of physiology in the UK College of Medicine, and first author Nicholas J. Constantino, Ph.D., a recent UK doctoral graduate, revealed that microglia are the primary drivers of sleep loss. By using a drug to temporarily remove these cells in animal models, the researchers successfully restored over two hours of sleep per day, providing a new target for treating the disease that Macauley described as "paradigm shifting."

July 20, 2026


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