News for Healthier Living
MOCCI-Driven Metabolic Reprogramming Promotes Lymph Node Metastasis in Lung Cancer
 Lymph node metastasis is associated with poor prognosis in lung cancer, but the role of tumor metabolism in this process remains unclear. This study identifies a primary lymph node metastatic cancer cell (PLMC) subgroup characterized by MOCCI-driven oxidative phosphorylation (OXPHOS) reprogramming. MOCCI enhanced mitochondrial respiration in lung cancer cells and promoted lymph node metastasis in mice. Spatial analyses linked MOCCI-positive PLMCs, through GDF15-TGFBR2 signaling, to follicular helper T (Tfh) cell exhaustion and suppression of adjacent B-cell activation. The findings link metabolic adaptation to immune remodeling during dissemination and suggest a potential target for intercepting lymph node metastasis.
November 12, 2026
November 12 2026November 11 2026November 10 2026November 9 2026 - Sylvester Researchers Identify DNA Marker That Could Predict Treatment Response in MDS
- Effective Obesity Treatments Reach Few Eligible Teens, Study Finds
- Potentially Deadly Soil Bacterium Gaining Foothold in New Regions, Including U.S.
- What Causes Pulmonary Fibrosis on a Cellular Level?
- Preclinical Findings Show Experimental Drug Eliminates 75% of Aggressive Pancreatic Tumors and Enhances Immune System Memory to Fight Other Cancers
- Eating and Sleeping Late Linked to Higher Health Risks, Study Finds
- Singing in a Choir Strengthens Breathing, Boosts Wellbeing in Kids Born with Single Heart Ventricle, Study Finds
- Tobacco Use Is Associated With Fecal Incontinence, Increased Rectal Hypersensitivity
- FSU Co-Authored Study Finds Visuals, Numbers Can Shape Perceptions of Lyme Disease Risk
- Decision-Making About Nutrition for Preemies Can Be a Challenge During Busy Rounds
- When Is the Right Time for TPIAT in Children With Pancreatitis?
- Two HSS Rheumatologists Receive Prestigious National Career Honors at Annual American College of Rheumatology Meeting
- US Youths See Nearly 4,000 Food Marketing Messages on Digital Media Each Year
- Early Trial Results Suggest Potential New Treatment for Stiff Person Syndrome
- Wake Forest Institute for Regenerative Medicine Research Aboard International Space Station Examines Chemotherapy Effectiveness
- Case Western Reserve researcher will use $3.1M VA grant to prevent bedsores in spinal cord injury patients
- The Era of Repeat Open-Heart Surgery is Ending: Hackensack Meridian Hackensack University Medical Center Offers Minimally Invasive Fix for Leaky Valves
- SITC 2026: UT MD Anderson Highlights Advances in Cancer Immunotherapy
- Liver Transplant Linked to Significantly Extended Survival for Alcohol-Associated Liver Disease; Women, African Americans Less Likely to Receive Transplants
- Women who Binge Drink at Least Once a Month are at Heightened Risk of Advanced Fibrosis, Study Suggests
- Expressive Writing May Help Reduce Negative Alcohol-Related Consequences Among People Prone to Heavy Drinking, Study Suggests
- Cannabis Use Linked to Higher Death Rates in People with Alcohol-associated Hepatitis
- Astrocytes Supporting Brain Activity Coordinate Neuronal and Cerebral Blood Flow Responses
- Blood Marker Shows Promise for Tracking Oxaliplatin-Related Nerve Damage
- Biomimetic nanoparticle combines antibacterial and regenerative actions for periodontitis
- ASH 2026 Tip Sheet: Sylvester Researchers Contribute to Dozens of Oral Presentations at American Society of Hematology Annual Meeting
- Researchers Reveal How Inhaled Nanoplastics Trigger Lung Inflammation
November 8 2026November 7 2026November 6 2026November 5 2026November 4 2026November 3 2026November 2 2026November 1 2026October 30 2026October 29 2026
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